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KMID : 0545120190290081184
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 8 p.1184 ~ p.1192
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Structure and Function of the Influenza A Virus Non-Structural Protein 1
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Han Chang-Woo
Jeong Mi-Suk
Jang Se-Bok
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Abstract
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The influenza A virus is a highly infectious respiratory pathogen that sickens many people with respiratory disease annually. To prevent outbreaks of this viral infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed. The influenza A virus can infect mammalian species including humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the new host and leads to pandemics. Most influenza A viruses express proteins that antagonize the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A virus is the most important viral regulatory factor controlling cellular processes to modulate host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response. This review focuses on the influenza A virus NS1 protein and outlines current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.
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KEYWORD
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Influenza A virus, NS1, virus-host interaction, antiviral defense, inhibitor
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